{"id":1082,"date":"2024-05-03T08:00:59","date_gmt":"2024-05-03T11:00:59","guid":{"rendered":"https:\/\/cursaueducacao.com.br\/blog\/?p=1082"},"modified":"2024-09-17T15:40:04","modified_gmt":"2024-09-17T18:40:04","slug":"fagocitose","status":"publish","type":"post","link":"https:\/\/cursaueducacao.com.br\/blog\/fagocitose\/","title":{"rendered":"Como acontece a fagocitose?"},"content":{"rendered":"\n

Com certeza voc\u00ea aprendeu o que \u00e9 fagocitose durante as aulas de imunologia da faculdade. Mas voc\u00ea sabe como esse processo acontece? A fagocitse \u00e9 um mecanismo no qual c\u00e9lulas como macr\u00f3fagos e neutr\u00f3filos, engolfam e digerem part\u00edculas estranhas, como bact\u00e9rias, v\u00edrus, c\u00e9lulas mortas e detritos celulares. Ela \u00e9 fundamental para a defesa do organismo contra pat\u00f3genos e para a remo\u00e7\u00e3o de material indesejado. Vamos explorar esse processo em detalhes, desde o reconhecimento at\u00e9 a destrui\u00e7\u00e3o da part\u00edcula fagocitada.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Reconhecimento e liga\u00e7\u00e3o:<\/h2>\n\n\n\n
    \n
  1. Quimiotaxia:<\/strong> Primeiramente, as c\u00e9lulas fagoc\u00edticas s\u00e3o atra\u00eddas para o local da infec\u00e7\u00e3o ou les\u00e3o por meio de quimiocinas e citocinas liberadas por pat\u00f3genos, c\u00e9lulas danificadas ou c\u00e9lulas do sistema imunol\u00f3gico.<\/li>\n\n\n\n
  2. Reconhecimento:<\/strong> As c\u00e9lulas fagoc\u00edticas reconhecem e se ligam \u00e0s part\u00edculas por meio de receptores de superf\u00edcie, como os receptores de padr\u00e3o de reconhecimento (PRRs). Ocorre ent\u00e3o o reconhecimento dessas mol\u00e9culas presentes na superf\u00edcie dos pat\u00f3genos ou marcadores de opsoniza\u00e7\u00e3o.<\/li>\n\n\n\n
  3. Forma\u00e7\u00e3o do Fagossomo:<\/strong> Ap\u00f3s a liga\u00e7\u00e3o, a membrana plasm\u00e1tica da c\u00e9lula fagoc\u00edtica se projeta ao redor da part\u00edcula estranha a fim de formar uma ves\u00edcula chamada fagossomo.<\/li>\n<\/ol>\n\n\n\n

    <\/p>\n\n\n\n

    Digest\u00e3o e destrui\u00e7\u00e3o:<\/h2>\n\n\n\n
      \n
    1. Fus\u00e3o com lisossomos:<\/strong> O fagossomo formado se funde com os lisossomos, organelas que cont\u00eam enzimas digestivas, formando um fagolisossomo.<\/li>\n\n\n\n
    2. Digest\u00e3o:<\/strong> As enzimas lisossomais, como proteases, nucleases e lipases, s\u00e3o liberadas no fagolisossomo e come\u00e7am a digerir a part\u00edcula fagocitada, quebrando-a em componentes menores.<\/li>\n\n\n\n
    3. Produ\u00e7\u00e3o de esp\u00e9cies reativas de oxig\u00eanio (ROS):<\/strong> Por fim, as c\u00e9lulas fagoc\u00edticas produzem esp\u00e9cies reativas de oxig\u00eanio, como o \u00e2nion super\u00f3xido (O2-), o per\u00f3xido de hidrog\u00eanio (H2O2) e o radical hidroxila (OH-), que s\u00e3o t\u00f3xicos para pat\u00f3genos e contribuem para a sua destrui\u00e7\u00e3o.<\/li>\n<\/ol>\n\n\n\n

      <\/p>\n\n\n\n

      \"a<\/figure>\n\n\n\n

      Resposta imune:<\/h2>\n\n\n\n
        \n
      1. Apresenta\u00e7\u00e3o de ant\u00edgeno:<\/strong> Durante a fagocitose, as c\u00e9lulas fagoc\u00edticas processam os ant\u00edgenos dos pat\u00f3genos e os apresentam na superf\u00edcie celular por meio de mol\u00e9culas do complexo de histocompatibilidade (MHC), iniciando uma resposta imune adaptativa.<\/li>\n\n\n\n
      2. Libera\u00e7\u00e3o de citocinas:<\/strong> As c\u00e9lulas fagoc\u00edticas liberam tamb\u00e9m citocinas pr\u00f3-inflamat\u00f3rias, como interleucina-1 (IL-1) e fator de necrose tumoral alfa (TNF-\u03b1), que estimulam a resposta inflamat\u00f3ria e a ativa\u00e7\u00e3o de outras c\u00e9lulas do sistema imunol\u00f3gico.<\/li>\n<\/ol>\n\n\n\n

        <\/p>\n\n\n\n

        Gostou? Conhe\u00e7a nossos treinamentos:<\/h2>\n\n\n\n

        Curso de coleta<\/a>
        Plataforma cursau<\/a> (com mais de 800H de conte\u00fado e grupo vip)
        P\u00f3s gradua\u00e7\u00f5es:         micro<\/a>, an\u00e1lises<\/a> e per\u00edcia<\/a><\/h4>\n\n\n\n

        <\/p>\n\n\n\n

        Refer\u00eancia bibliogr\u00e1fica: <\/p>\n\n\n\n

        ABBAS, Abul K.; PILLAI, Shiv; LICHTMAN, Andrew H.. Imunologia celular e molecular. 9 Rio de Janeiro: Guanabara Koogan, 2019, 565 p.<\/p>\n","protected":false},"excerpt":{"rendered":"

        Com certeza voc\u00ea aprendeu o que \u00e9 fagocitose durante as aulas de imunologia da faculdade. Mas voc\u00ea sabe como esse processo acontece? A fagocitse \u00e9 um mecanismo no qual c\u00e9lulas como macr\u00f3fagos e neutr\u00f3filos, engolfam e digerem part\u00edculas estranhas, como bact\u00e9rias, v\u00edrus, c\u00e9lulas mortas e detritos celulares. Ela \u00e9 fundamental para a defesa do organismo […]<\/p>\n","protected":false},"author":5,"featured_media":1084,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,7],"tags":[217,47,168,207,199,67,126],"class_list":["post-1082","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-imunologia","category-saude-basica","tag-biomed","tag-biomedicina","tag-biomedico","tag-habilitacao","tag-habilitacoes","tag-imuno","tag-imunologia"],"yoast_head":"\nComo acontece a fagocitose? - Cursau Educa\u00e7\u00e3o - Blog<\/title>\n<meta name=\"description\" content=\"Neste post voc\u00ea ir\u00e1 aprender como funciona o passo a passo do processo de fagocitose, desde o reconhecimento at\u00e9 a destrui\u00e7\u00e3o da part\u00edcula.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cursaueducacao.com.br\/blog\/fagocitose\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Como acontece a fagocitose? 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